Agilent, GKIB-002, AdvanceBio InstantAB Bovine fetuin N-glycan Library

AdvanceBio InstantAB Bovine fetuin N-glycan Library. Composed of a mixture of sialylated N-linked glycans (core non-fucosylated), consistent with N-glycans previously reported for bovine fetuin. The biantennary glycans can have one or two of the sialic acid residues (NeuAc); the triantennary glycans can have from one to four of the sialic acid residues. The sialic acid residues are found in both α(2,3) and α(2,6) linkages. Triantennary glycans constitute ~85% of total glycans present. A small amount of penta-sialylated glycans can be detected, but their structure has not been determined. The reducing termini are derivatized with the fluorescent dye, InstantAB.

Specifications:
Label: InstantAB
Unit: 70 pmol

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This comprehensive N-glycan library provides a highly characterized profile of bovine fetuin derived oligosaccharides, fluorescently labeled for immediate use in glycan analysis workflows. It supports rapid and confident identification of N-glycans in biopharmaceutical development, enabling robust method development, system suitability testing, and glycan structure assignment. Optimized for use with the AdvanceBio InstantAB labeling chemistry, this library is ideal for HILIC-UPLC, UHPLC, and LC-MS. Typical users include scientists in quality control, analytical development, and research laboratories studying protein glycosylation patterns or biosimilar comparisons.

Each library includes a diverse set of well-characterized N-glycan standards, enhancing accuracy when benchmarking glycan release and analysis protocols. It streamlines sample preparation and data analysis for workflows using Agilent AdvanceBio Glycan Mapping columns and is fully compatible with Agilent 1260 and 1290 Infinity series LC systems. The kit ensures reliable peak assignments and assists with glycan quantitation during method validation. Additionally, it integrates seamlessly with MassHunter and OpenLab software for efficient data processing and reporting. This library is an essential reference material for researchers seeking reproducible, high-quality glycan analysis in biologics characterization and quality assurance settings.