Agilent, GKIB-315, AdvanceBio InstantAB G2FS1 α(2,6) / FA2G2S(6)1 N-glycan Standard

AdvanceBio InstantAB G2FS1 α(2,6) / FA2G2S(6)1 N-glycan Standard. N-glycan (mono-sialylated, galactosylated biantennary, core-substituted with fucose) labeled with InstantAB, for use as a qualitative standard in applications such as liquid chromatography (LC). Alternative glycan names: FA2G2S1, F(6)A2G2S1, F(6)A2G(4)2S(6)1, A1F.

Specifications:
Chemical Structure:
Label: InstantAB
Monoisotopic Mass: MWGlycan + 161.05891 = 2238.8044
Name: G2FS1 (α2,6)
Oxford Name: F(6)A2G(4)2S(6)1
Standard Type: Complex-type Native N-Glycan
Unit: 60 pmol

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This N-glycan standard offers a well-characterized sample of α(2,6)-sialylated FA2G2S(6)1 glycan, labeled with the robust InstantAB dye for optimal fluorescence and mass spectrometric detection. Designed to streamline and validate N-linked glycan analysis workflows, it provides a reliable reference for method development, system suitability testing, and quantitation in biopharmaceutical research. By integrating this standard into analytical procedures, users can efficiently evaluate labeling performance, instrument sensitivity, and chromatographic separation quality. It is particularly valuable in the assessment of glycosylation structures for monoclonal antibodies, therapeutic proteins, and biosimilars, supporting regulatory compliance and quality assurance programs. Compatibility with Agilent AdvanceBio Glycan Mapping columns, InfinityLab LC systems, and mass spectrometry platforms ensures seamless application in high-resolution, high-throughput environments. Researchers can utilize this standard alongside other Agilent glycan standards for detailed profiling, identification, and quantitation of N-glycan species. Its ease of reconstitution and stable labeling chemistry allow for reproducible results, critical in method validation and lot-to-lot comparison studies. The product is an essential tool for glycan characterization in laboratories focused on advanced biotherapeutic development and quality control.