Agilent, GKPC-315, AdvanceBio InstantPC G2FS1 α(2,6) / FA2G2S(6)1 N-glycan standard

AdvanceBio InstantPC G2FS1 α(2,6) / FA2G2S(6)1 N-glycan standard . N-glycan (mono-α(2,6)-sialylated, galactosylated biantennary, core-substituted with fucose) labeled with InstantPC, for use as a qualitative standard in applications such as liquid chromatography (LC) and mass spectrometry (MS). Alternative glycan names: G2FS1, FA2G2S1, F(6)A2G(4)2S(6)1, A1F.

Specifications:
Chemical Structure:
Label: InstantPC
Monoisotopic Mass: MWGlycan + 261.14773 = 2338.8932
Name: G2FS1 (α2,6)
Oxford Name: F(6)A2G(4)2S(6)1
Standard Type: Complex-type Native N-Glycan
Unit: 25 Injections

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This N-glycan standard offers precise quantitation and confident structural elucidation of complex glycans in biopharmaceutical analysis. Carefully characterized to contain both α(2,6)-linked sialylated glycan (G2FS1 α(2,6)) and doubly galactosylated, singly sialylated, core-fucosylated N-glycan (FA2G2S(6)1), it enables analysts to verify retention times, monitor system suitability, and support method development for released N-glycan profiling. Labeled with InstantPC, the standard delivers enhanced fluorescence sensitivity and MS response, ensuring accurate detection during UPLC, LC-MS, and HPLC workflows. Ideal for quality control, comparability assessments, and characterization of therapeutic monoclonal antibodies, it supports regulatory compliance by facilitating robust method validation. Optimized for compatibility with the Agilent AdvanceBio Glycan Mapping workflow, it integrates seamlessly with Agilent 1290 Infinity LC, 1260 Infinity II Bio LC, and 6545XT AdvanceBio LC/Q-TOF systems. The standard complements other glycan standards and sample preparation kits in the Agilent AdvanceBio portfolio, enabling efficient and reproducible glycan analysis in both discovery and routine settings. Its reliability and defined composition make it a valuable tool for laboratories aiming to achieve high confidence in glycan identification and quantitation across a broad range of biotherapeutic research and development applications.