Agilent, GKPC-325, AdvanceBio InstantPC G2FS1 α(2,3) / FA2G2S(3)1 N-glycan standard

AdvanceBio InstantPC G2FS1 α(2,3) / FA2G2S(3)1 N-glycan standard . N-glycan (mono-α(2,3)-sialylated, galactosylated biantennary, core-substituted with fucose)labeled with InstantPC, for use as a qualitative standard in applications such as liquid chromatography (LC) and mass spectrometry (MS). Alternative glycan names: A1F (α2,3), G2FS1, FA2G2S1, F(6)A2G(4)2S(3)1.

Specifications:
Chemical Structure:
Label: InstantPC
Monoisotopic Mass: MWGlycan + 261.14773 = 2338.8932
Name: G2FS1 (α2,3)
Oxford Name: F(6)A2G(4)2S(3)1
Standard Type: Complex-type Native N-Glycan
Unit: 25 Injections

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This N-glycan standard enables precise and reliable glycan identification in biopharmaceutical analysis. Labeled with the InstantPC fluorescent dye, the reference material contains well-characterized α2,3-linked sialylated (G2FS1 α2,3) and core-fucosylated biantennary (FA2G2S(3)1) glycans, ideal for accurate method validation and quantitation of complex glycosylation profiles. Its robust lot-to-lot consistency and strong fluorescent response streamline glycan analysis, ensuring high reproducibility and sensitivity across workflows.

Optimized for rapid sample preparation, this standard is suitable for HILIC-UPLC, UPLC, and LC-MS platforms. It serves a central role in glycoprotein characterization, QC release testing, and comparability studies for therapeutic monoclonal antibodies and other glycoprotein therapeutics development. Additionally, it supports routine calibration and system suitability testing for critical quality attributes throughout bioprocess development.

Compatible with Agilent’s AdvanceBio Glycan Mapping Kits, Bio LC systems, and InfinityLab LC platforms, it integrates seamlessly into established workflows for glycan profiling. Researchers benefit from established protocols to achieve precise glycan structure determination, method development, and validation. The standard is an essential tool for analytical and research laboratories focused on protein characterization and ensures confidence in glycan-based biotherapeutics development and regulatory submission.