Agilent, GKSA-002, AdvanceBio 2-AA Bovine Fetuin N-glycan Library

AdvanceBio 2-AA Bovine Fetuin N-glycan Library. Composed of a mixture of sialylated N-linked glycans (core non-fucosylated), consistent with N-glycans previously reported for bovine fetuin. The biantennary glycans can have one or two of the sialic acid residues (NeuAc). The triantennary glycans can have from one to four of the sialic acid residues. The sialic acid residues are found in both (2,3) and (2,6) linkages. Triantennary glycans constitute ~85% of total glycans present. A small amount of penta-sialylated glycans can be detected, but their structure has not been determined. The reducing termini are derivatized with the fluorescent dye, 2-AA.

Specifications:
Label: 2-AA
Unit: 200 pmol

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The AdvanceBio 2-AA Bovine Fetuin N-glycan Library is a high-quality reference standard designed for the identification and characterization of N-linked glycans in biopharmaceutical research. This library contains purified N-glycans from bovine fetuin, each labeled with 2-aminobenzoic acid 2-AA, enabling enhanced fluorescence detection and mass spectrometric analysis. Researchers can use this standard in a range of workflows, including glycan profiling, method development, and system suitability assessments for glycomics studies. It is particularly valuable for laboratories working on biologic drug development, comparability studies, and quality control, where accurate N-glycan characterization is essential. The library is optimized for use with Ultra High Performance Liquid Chromatography UHPLC, High Performance Liquid Chromatography HPLC, as well as CE and LC-MS platforms. It is fully compatible with Agilent AdvanceBio Glycan Mapping columns and associated reagents, supporting streamlined integration into existing glycan analysis protocols. Clear documentation and glycan profiles are provided, allowing confident assignment and analytical reproducibility across both routine and advanced applications. By providing a trusted benchmark for N-glycan quantitation and identification, this standard helps ensure robust data quality and regulatory compliance in carbohydrate research and QC laboratories.