Agilent, GKSA-005, AdvanceBio 2-AA Human IgG N-glycan library

AdvanceBio 2-AA Human IgG N-glycan library. AdvanceBio 2-AA Human IgG N-glycan library (formerly ProZyme) consists of complex biantennary oligosaccharides consistent with N-glycans on normal human IgG. The reducing termini are derivatized with the fluorescent dye, 2-AA.

Specifications:
Label: 2-AA
Unit: 200 pmol

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The AdvanceBio 2-AA Human IgG N-glycan library provides a comprehensive reference standard of 2-aminobenzoic acid labeled N-glycans derived from human immunoglobulin G. This ready-to-use library is designed to support efficient glycan profiling, structure assignment, and method optimization in biopharmaceutical development and quality control. The product enables users to confidently identify and quantify a broad range of critical glycoforms, facilitating comparability studies and characterization of therapeutic antibodies.

Ideal for use in analytical workflows using LC fluorescence, LC mass spectrometry, and capillary electrophoresis, the library enhances the accuracy and reproducibility of glycan analysis. It streamlines method validation for laboratories engaged in biosimilar development, antibody engineering, or glycosylation-related research. The glycan standards are compatible with Agilent AdvanceBio Glycan Mapping columns, 1290 Infinity II LC systems, CE systems, and associated sample preparation kits, allowing seamless integration into existing workflows.

This library is a valuable tool for researchers seeking to improve the reliability of N-glycan identification and quantitation in workflow development, regulatory submissions, or routine quality control. It supports compliance with industry guidelines by providing well-characterized reference materials essential for robust analytical performance.