Agilent, GKSA-106, AdvanceBio 2-AA Man8 / M8 N-glycan standard (formerly ProZyme)

AdvanceBio 2-AA Man8 / M8 N-glycan standard (formerly ProZyme). N-glycan (oligomannose 8) labeled with 2-aminobenzoic acid (2-AA, also known as anthranilic acid), for use as a qualitative standard in applications such as liquid chromatography (LC).

Specifications:
Chemical Structure:
Label: 2-AA
Monoisotopic Mass: MWGlycan + 121.05276 = 1841.6445
Name: Man8
Oxford Name: M8
Standard Type: High Mannose-type Native N-Glycan
Unit: 100 pmol

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The AdvanceBio 2-AA Man8 M8 N-glycan standard is a highly purified, pre-labeled N-glycan reference designed for reliable and reproducible analysis of biopharmaceutical glycosylation. Labeled with 2-aminobenzoic acid (2-AA), this standard facilitates sensitive detection and quantitation of mannose-rich N-glycan species, particularly the Man8 (M8) structure. It is ideal for quality control, method development, and system calibration in glycomics studies related to biotherapeutics, biosimilars, and glycoprotein characterization.

Optimized for high-resolution liquid chromatography and mass spectrometry workflows, this standard is compatible with a broad range of analytical platforms, including Agilent AdvanceBio Glycan Mapping columns, HPLC, UHPLC, and CE-LIF systems. Its use enhances accuracy in retention time alignment and ensures robust glycan identification when profiling complex biological samples. Researchers working in pharmaceutical development, biomarker discovery, and glycoprotein analysis will benefit from the product's lot-to-lot consistency and batch traceability. Additionally, it serves as an essential control for validating sample preparation procedures in laboratories adhering to rigorous regulatory standards. The standard complements Agilent's suite of glycan analysis reagents and instrumentation, supporting comprehensive glycan characterization workflows.