Agilent, GKSA-311, AdvanceBio 2-AA G2S1 α(2,6) / A2G2S(6)1 N-glycan standard (formerly ProZyme)

AdvanceBio 2-AA G2S1 α(2,6) / A2G2S(6)1 N-glycan standard (formerly ProZyme). N-glycan (mono-sialylated, galactoyslated biantennary) labeled with 2-aminobenzoic acid (2-AA, also known as anthranilic acid), for use as a qualitative standard in applications such as liquid chromatography (LC). Alternative glycan names: A2G2S1, A2G(4)2S(6)1, A1.

Specifications:
Chemical Structure:
Label: 2-AA
Monoisotopic Mass: MWGlycan + 121.05276 = 2052.7403
Name: G2S1 (α2,6)
Oxford Name: A2G(4)2S(6)1
Standard Type: Complex-type Native N-Glycan
Unit: 100 pmol

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This highly purified N-glycan standard is designed for robust and reliable glycan analysis in biopharmaceutical and academic research settings. Labeled with 2-aminobenzoic acid (2-AA), the α(2,6) linked sialylated glycan standard enables accurate identification and quantification of complex N-glycan structures, particularly those relevant to therapeutic proteins and monoclonal antibodies. The glycans are pre-isolated and characterized, making them ideal controls or references for HPLC, UPLC, LC-MS, and capillary electrophoresis workflows.

The standard supports comprehensive method development, system suitability testing, and instrument calibration, facilitating assay reproducibility and compliance with regulatory requirements. It is widely used in structural elucidation, profiling, and monitoring of glycosylation patterns in proteins. The material is fully compatible with Agilent’s AdvanceBio Glycan Mapping columns and workflows, and suitable for use with instruments including Agilent 1260 Infinity II, 1290 Infinity LC systems, and comparable LC-MS platforms.

Recommended for research professionals working in bioprocess development, quality control, and glycomics research, this standard aids in the detection and quantitation of α(2,6) sialylated glycan species. Cross-compatibility with similar standards in the AdvanceBio and ProZyme product lines makes it versatile for comprehensive glycan studies.