Agilent, GKSA-315, AdvanceBio 2-AA G2FS1 α(2,6) / FA2G2S(6)1 N-glycan Standard

AdvanceBio 2-AA G2FS1 α(2,6) / FA2G2S(6)1 N-glycan Standard. N-glycan (mono-sialylated, galactosylated biantennary, core-substituted with fucose) labeled with 2-aminobenzoic acid (2-AA, also known as anthranilic acid), for use as a qualitative standard in applications such as liquid chromatography (LC). Alternative glycan names: G2FS1, FA2G2S1, F(6)A2G(4)2S(6)1, A1F.

Specifications:
Chemical Structure:
Label: 2-AA
Monoisotopic Mass: MWGlycan + 121.05276 = 2198.7982
Name: G2FS1 (α2,6)
Oxford Name: F(6)A2G(4)2S(6)1
Standard Type: Complex-type Native N-Glycan
Unit: 100 pmol

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This high-purity N-glycan standard enables accurate and reliable evaluation of glycosylation in biopharmaceutical research and quality control. Labeled with 2-aminobenzoic acid (2-AA), the compound features α(2,6)-linked sialic acid and a single FA2G2S(6)1 glycoform, facilitating quantitative and qualitative analyses of released glycan profiles. Researchers can confidently use this standard for system suitability testing, method development, or peak assignment when characterizing therapeutic monoclonal antibodies, fusion proteins, or other glycoproteins.

Optimized for compatibility with Agilent AdvanceBio Glycan Mapping columns, liquid chromatography, and mass spectrometry systems, this reference standard delivers consistent retention times and spectral responses. It is ideally suited for laboratories developing GMP-compliant methods, performing batch-to-batch comparability studies, or validating glycan identification in high-throughput workflows. Additionally, the standard supports orthogonal approaches such as CE-LIF or UPLC-FLD when paired with suitable detection equipment.

Agilent also offers a complete portfolio of glycan sample preparation kits and profiling standards for streamlined workflows. Incorporating this standard into analytical protocols increases confidence in glycan assignment and ensures regulatory compliance in biotherapeutic production or advanced glycobiology research.