Agilent, GKSB-001, AdvanceBio 2-AB Human α-1-acid glycoprotein N-glycan Library

AdvanceBio 2-AB Human α-1-acid glycoprotein N-glycan Library. Represents a total pool of N-linked glycans released from Human alpha-1-acid glycoprotein (AGP). These glycans constitute a heterogenous mixture of core non-fucosylated bi-, tri- and tetraantennary glycans with various degrees of sialylation (NeuAc) and some with outer arm fucose residues and lactosamine repeats, consistent with N-glycans previously reported for human α1-acid glycoprotein. The biantennary glycans can have one or two sialic acid residues. The triantennary and tetraantennary glycans can have from one to four sialic acid residues and may be substituted with fucose which results in formation of sialyl Lewis X-like structure.

Specifications:
Label: 2-AB
Unit: 200 pmol

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This specialized N-glycan library delivers a comprehensive reference panel of 2-aminobenzamide labeled N-glycans released from human alpha-1-acid glycoprotein. Designed for streamlined and accurate glycan profiling, it is ideally suited for use in biopharmaceutical development, quality control, and biomarker discovery. The well-characterized glycan standards facilitate confident identification, quantitation, and structural elucidation of complex glycosylation patterns in therapeutic proteins or other biological samples.

The library is fully compatible with a range of advanced analytical platforms, including high-performance liquid chromatography with fluorescence detection and liquid chromatography coupled to mass spectrometry. It integrates seamlessly with Agilent AdvanceBio Glycan Mapping columns, 1290 Infinity II LC Systems, and MassHunter software, supporting high-resolution separation and robust data analysis. Researchers in glycomics, biotechnology, and pharmaceutical quality assurance can utilize this resource for method validation, system suitability assessment, or development of new analytical workflows focused on glycan analysis. Use of the library accelerates confidence in N-glycan assignments and enhances consistency across laboratories, supporting regulatory compliance and facilitating decision-making in process development and product characterization.