Agilent, GKSB-101, AdvanceBio 2-AB Man3 / M3 N-glycan Standard

AdvanceBio 2-AB Man3 / M3 N-glycan Standard. N-glycan (conserved trimannosyl core) labeled with 2-aminobenzamide (2-AB), for use as a qualitative standard in applications such as liquid chromatography (LC). Alternative glycan names: M3N2, MAN-3.

Specifications:
Chemical Structure:
Label: 2-AB
Monoisotopic Mass: MWGlycan + 120.06875 = 1030.3965
Name: Man3
Oxford Name: M3
Standard Type: Native N-Glycan Core
Unit: 100 pmol

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This high-purity N-glycan standard is specifically designed for researchers engaged in glycan analysis of biotherapeutics, allowing precise method development, system qualification, and performance monitoring. Provided as a 2-AB labeled Man3 M3 structure, it supports accurate retention time assignment and system calibration in HILIC-UPLC, HPLC, or LC-MS workflows. Ideal for laboratories working with monoclonal antibodies, biosimilars, or glycoproteins, this standard enables confident glycosylation profiling and structural comparison across batches or experimental runs.

Suitable for use with Agilent AdvanceBio Glycan Mapping columns and compatible detection platforms, it integrates seamlessly into established glycan characterization protocols. Typical applications include confirming instrument sensitivity, validating separation integrity, and quantifying glycan recovery. It is also valuable for troubleshooting and optimizing sample preparation procedures in regulated or research environments.

Each lot undergoes stringent quality control to ensure consistency and reliable performance. This glycan reference is also compatible with Agilent sample preparation kits and can be incorporated into quantitative assays or profiling kits alongside other synthetic standards. Researchers benefit from its robust characterization and reproducibility for critical quality attribute assessments in bioanalytical workflows.