Agilent, GKSB-104, AdvanceBio 2-AB Man6 / M6 N-glycan Standard

AdvanceBio 2-AB Man6 / M6 N-glycan Standard. N-glycan (oligomannose 6) labeled with 2-aminobenzamide (2-AB), for use as a qualitative standard in applications such as liquid chromatography (LC).

Specifications:
Chemical Structure:
Label: 2-AB
Monoisotopic Mass: MWGlycan + 120.06875 = 1516.5549
Name: Man6
Oxford Name: M6
Standard Type: High Mannose-type Native N-Glycan
Unit: 100 pmol

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This N-glycan standard provides a highly purified Man6 (mannose 6) oligosaccharide labeled with 2-AB, suitable for method development, quality control, and system suitability testing in glycan analysis workflows. Each vial contains a precise quantity of 2-aminobenzamide (2-AB) labeled Man6, enabling robust performance monitoring and calibration for HPLC, UHPLC, and LC-MS systems in biopharmaceutical and glycomics laboratories. This standard is essential for accurate identification and quantification of high mannose structures during glycan profiling of therapeutic antibodies and other glycoproteins. It supports comparability studies, lot release testing, and glycosylation assessment by serving as a reference material. The product is fully compatible with Agilent AdvanceBio Glycan Mapping columns and comprehensive glycan preparation kits, ensuring seamless integration into existing workflows. It may also be used in conjunction with other labeled glycan standards to generate calibration curves or validate system response. Carefully prepared for consistency, this standard provides reproducible retention times, sharp peaks, and reliable signal intensity, facilitating detailed structural characterization and compliance with regulatory guidelines. Ideal for researchers seeking robust, high-quality reference materials to support method validation, data interpretation, and quality assurance in glycan analysis.