Agilent, GKSB-306, AdvanceBio 2-AB G2FB / FA2BG2 N-glycan Standard

AdvanceBio 2-AB G2FB / FA2BG2 N-glycan Standard. N-glycan (asialo-, galactosylated biantennary N-glycan, core substituted with fucose and with bisecting GlcNAc) labeled with 2-aminobenzamide (2-AB), for use as a qualitative standard in applications such as liquid chromatography (LC). Alternative glycan names: F(6)A2BG2, F(6)A2BG(4)2, NA2FB.

Specifications:
Chemical Structure:
Label: 2-AB
Monoisotopic Mass: MWGlycan + 120.06875 = 2109.7982
Name: G2FB
Oxford Name: F(6)A2BG(4)2
Standard Type: Complex-type Native N-Glycan
Unit: 100 pmol

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The AdvanceBio 2-AB G2FB / FA2BG2 N-glycan Standard is designed for robust and reliable glycan analysis in biopharmaceutical and glycomics research. This standard aids in the identification and quantification of complex biantennary N-glycan structures labeled with 2-aminobenzamide for improved fluorescence detection sensitivity. It is ideal for the validation and calibration of HPLC, UHPLC, UPLC, and capillary electrophoresis workflows, facilitating precise method development, system suitability testing, and routine quality control of glycoprotein therapeutics.

Researchers utilize this standard to benchmark system performance, confirm glycan profiling accuracy, and ensure reproducible data, essential for the development and characterization of biologics such as monoclonal antibodies and fusion proteins. The standard is fully compatible with Agilent AdvanceBio Glycan Mapping columns, Glycan Analysis Kits, and a wide array of Agilent LC and CE instruments. It can be seamlessly integrated into existing workflows alongside other glycan standards for a comprehensive analysis suite. With its consistent lot-to-lot quality and traceability, this standard ensures confidence in glycan structure assignment and quantitative analysis, supporting both discovery and regulatory submission studies in academic, biotech, and pharmaceutical laboratories.