Agilent, GKSB-307, AdvanceBio 2-AB A3 N-glycan Standard

AdvanceBio 2-AB A3 N-glycan Standard. N-glycan (asialo-, agalacto-, triantennary) labeled with 2-aminobenzamide (2-AB), for use as a qualitative standard in applications such as liquid chromatography (LC). Alternative glycan name: NGA3.

Specifications:
Chemical Structure:
Label: 2-AB
Monoisotopic Mass: MWGlycan + 120.06875 = 1639.6347
Name: A3
Oxford Name: A3
Standard Type: Complex-type Native N-Glycan
Unit: 100 pmol

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This N-glycan standard is a highly purified, well-characterized mixture of 2-AB labeled A3 glycans, designed to ensure accuracy and confidence in glycan analysis workflows. Optimized for use in biopharmaceutical research and quality control, it serves as a benchmark for method development, system suitability testing, and data normalization in the analysis of N-glycosylation patterns. The standard supports consistent glycan profile identification in monoclonal antibody characterization, biosimilar comparability assessment, and process monitoring.

Prepared for seamless compatibility with Agilent AdvanceBio Glycan Mapping columns, as well as HILIC HPLC and UHPLC systems, this reference material integrates easily into a variety of liquid chromatography-mass spectrometry (LC-MS) and fluorescence detection workflows. It facilitates robust retention time alignment and quantitation, streamlining data interpretation when working alongside other 2-aminobenzamide labeled glycan references. The standard is suitable for both manual and automated sample preparation and analysis protocols, making it ideal for regulated and non-regulated laboratory environments. By providing reliable and reproducible glycan profiles, this product empowers researchers to ensure analytical accuracy and to comply with rigorous industry standards throughout glycan characterization studies.