Agilent, GKSB-309, AdvanceBio 2-AB A4 N-glycan Standard

AdvanceBio 2-AB A4 N-glycan Standard. N-glycan (asialo-, agalacto-, tetraantennary complex N-glycan) labeled with 2-aminobenzamide (2-AB), for use as a qualitative standard in applications such as liquid chromatography (LC). Alternative glycan name: NGA4.

Specifications:
Chemical Structure:
Label: 2-AB
Monoisotopic Mass: MWGlycan + 120.06875 = 1842.7141
Name: A4
Oxford Name: A4
Standard Type: Complex-type Native N-Glycan
Unit: 100 pmol

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This robust N-glycan standard offers precise quantification and reliable performance for glycan analysis in biopharmaceutical research and quality control. Labeled with the 2-aminobenzamide (2-AB) fluorophore, the standard enables highly sensitive detection and identification of complex N-glycan structures derived from glycoproteins. It is meticulously characterized and optimized for use in high-performance liquid chromatography HILIC-UPLC, capillary electrophoresis, and mass spectrometry workflows.

Ideal for assay calibration, method development, and system suitability testing, this standard ensures consistent results with minimal lot-to-lot variability. It supports regulatory compliance during biologics development, lot release, and comparability studies. Researchers benefit from its compatibility with Agilent AdvanceBio Glycan Mapping columns, 1290 Infinity II LC systems, and LC-MS detectors. Additionally, this standard streamlines method optimization for both qualitative and quantitative glycan profiling in therapeutic antibody characterization.

For comprehensive analyses, this standard is frequently employed alongside Agilent’s broad selection of glycan labeling kits and reference materials. Its stability, ease of use, and traceable quality make it a fundamental component for laboratories pursuing high-confidence glycoprotein analytics and detailed bioprocess monitoring. This solution is essential for any laboratory demanding reproducible and accurate glycan analysis outcomes.