Agilent, GKSB-311, AdvanceBio 2-AB G2S1 α(2,6) / A2G2S(6)1 N-glycan Standard

AdvanceBio 2-AB G2S1 α(2,6) / A2G2S(6)1 N-glycan Standard. N-glycan (mono-sialylated-, galactosylated biantennary) labeled with 2-aminobenzamide (2-AB), for use as a qualitative standard in applications such as liquid chromatography (LC). Alternative glycan names: G2S1, A2G2S1, A2G(4)2S(6)1, A1.

Specifications:
Chemical Structure:
Label: 2-AB
Monoisotopic Mass: MWGlycan + 120.06875 = 2051.7563
Name: G2S1 (α2,6)
Oxford Name: A2G(4)2S(6)1
Standard Type: Complex-type Native N-Glycan
Unit: 100 pmol

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This high-purity N-glycan standard contains the well-characterized biantennary glycan structure with α(2,6)-linked sialic acid and 2-antennary core fucosylation, labeled with 2-aminobenzamide (2-AB) to facilitate fluorescence detection. It delivers reproducible retention times and reliable peak identification in liquid chromatography or mass spectrometry-based glycan profiling workflows. Designed for quantitative and qualitative accuracy, this standard ensures robust method development, system suitability assessment, and precise calibration during glycoprotein characterization studies, including therapeutic monoclonal antibody analysis and biopharmaceutical quality control. Researchers can confidently apply it to benchmark separation techniques, detect system variability, and streamline interlaboratory method transfer. The fluorescent 2-AB label enables high-sensitivity detection on HPLC or UHPLC systems equipped with fluorescence or mass spectrometric detectors. This standard seamlessly integrates with Agilent AdvanceBio Glycan Mapping columns, as well as compatible with a range of sample preparation kits and analytical instruments such as Agilent 1290 Infinity II LC systems and MassHunter software. It is an essential tool for analytical laboratories focused on detailed glycobiology, biosimilar comparability studies, and regulatory submissions where data traceability and analytical rigor are paramount.