Agilent, GKSB-312, AdvanceBio 2-AB G2S2 α(2,6) / A2G2S(6)2 N-glycan Standard

AdvanceBio 2-AB G2S2 α(2,6) / A2G2S(6)2 N-glycan Standard. N-glycan (di-sialylated-, galactosylated biantennary complex N-glycan) labeled with 2-aminobenzamide (2-AB), for use as a qualitative standard in applications such as liquid chromatography (LC). Alternative glycan names: G2S2, A2G2S2, A2G(4)2S(6)2, A2.

Specifications:
Chemical Structure:
Label: 2-AB
Monoisotopic Mass: MWGlycan + 120.06875 = 2342.8517
Name: G2S2 (α2,6)
Oxford Name: A2G(4)2S(6)2
Standard Type: Complex-type Native N-Glycan
Unit: 100 pmol

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The AdvanceBio 2-AB G2S2 α(2,6) / A2G2S(6)2 N-glycan Standard is an expertly characterized reference material engineered for accurate identification and quantitation of complex biantennary N-glycans featuring α(2,6) linked sialic acids. Designed for high sensitivity, it is labeled with 2-aminobenzamide (2-AB) for enhanced fluorescence detection and compatibility with HPLC, UPLC, LC-MS, and capillary electrophoresis platforms. This standard is ideal for validating analytical methods, calibrating equipment, and supporting glycan profiling during biotherapeutic development, quality control, and comparability studies. Researchers can use it to facilitate the identification of glycan isomers, monitor batch-to-batch consistency, and ensure regulatory compliance in biomanufacturing environments. The standard enables streamlined system suitability testing and is especially beneficial when analyzing monoclonal antibodies or glycoproteins with complex sialylation patterns. It integrates seamlessly with Agilent’s AdvanceBio Glycan Mapping columns, glycan sample preparation kits, and analysis software, providing a comprehensive workflow solution. Laboratories trusting in reliable and reproducible glycan analysis will find this standard essential for rigorous characterization and quantitation, supporting robust biopharmaceutical research and production.