Agilent, GKSB-314, AdvanceBio 2-AB G3S3 α(2,6) / A3G3S(6)3 N-glycan Standard

AdvanceBio 2-AB G3S3 α(2,6) / A3G3S(6)3 N-glycan Standard. N-glycan (tri-sialylated-, galactosylated triantennary complex)labeled with 2-aminobenzamide (2-AB), for use as a qualitative standard in applications such as liquid chromatography (LC). Alternative glycan names: G3S3, A3G3S3, A2G(4)3S(6)3, A3.

Specifications:
Chemical Structure:
Label: 2-AB
Monoisotopic Mass: MWGlycan + 120.06875 = 2999.0793
Name: G3S3 (α2,6)
Oxford Name: A3G(4)3S(6)3
Standard Type: Complex-type Native N-Glycan
Unit: 100 pmol

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The AdvanceBio 2-AB G3S3 α(2,6) / A3G3S(6)3 N-glycan Standard is a highly purified, fluorescently labeled N-glycan reference material designed to enhance the accuracy of glycan analysis in biopharmaceutical research and quality control. This oligosaccharide standard is ideal for method development, system suitability testing, comparative profiling, and peak identification workflows. Labeled with 2-aminobenzamide (2-AB), it supports sensitive detection and quantitation by hydrophilic interaction liquid chromatography with fluorescence detection HILIC-FLD, as well as mass spectrometry-based glycan analysis.

The well-defined structural characteristics and high purity make it an essential reference for those analyzing complex N-glycan profiles in monoclonal antibodies, recombinant therapeutics, and other glycoproteins. Applications include biosimilar development, lot-to-lot consistency monitoring, and glycoprofiling of novel biologics. The standard is fully compatible with Agilent AdvanceBio Glycan Mapping workflows, HPLC, UHPLC, and LC-MS systems, including Agilent 1260 Infinity II, 1290 Infinity II, and 6545XT AdvanceBio LC/Q-TOF platforms. It integrates seamlessly with AdvanceBio Glycan Mapping columns and related sample preparation kits, supporting robust and reproducible analytical workflows for academic, pharmaceutical, and regulatory laboratories.