Agilent, GKSP-315, AdvanceBio APTS G2FS1 α(2,6) / FA2G2S(6)1 N-glycan Standard

AdvanceBio APTS G2FS1 α(2,6) / FA2G2S(6)1 N-glycan Standard. N-glycan (mono-α(2,6)-sialylated, galactosylated biantennary, core-substituted with fucose) labeled with 8-aminopyrene-1,3,6-trisulfonate (APTS), for use as a qualitative standard in applications such as capillary electrophoresis (CE). Alternative glycan names: F(6)A2G(4)2S(6)1, FA2G2S1, A1F.

Specifications:
Chemical Structure:
Label: APTS
Monoisotopic Mass: MWGlycan + 440.9647 = 2518.7102
Name: G2FS1 (α2,6)
Oxford Name: F(6)A2G(4)2S(6)1
Standard Type: Complex-type Native N-Glycan
Unit: 60 pmol

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The AdvanceBio APTS G2FS1 α(2,6) / FA2G2S(6)1 N-glycan Standard is a highly purified reference standard designed for precise glycan analysis in biopharmaceutical development and quality control. This product is optimized for accurate identification and quantitation of sialylated N-glycan structures, specifically the G2FS1 α(2,6) / FA2G2S(6)1 isomer, following fluorescent labeling with 8-aminopyrene-1,3,6-trisulfonic acid (APTS). It plays a vital role in method development, system suitability testing, and the validation of analytical workflows focusing on glycosylation profiling. Suitable for use in research and manufacturing environments, this standard streamlines comparison with native glycans derived from monoclonal antibodies and other glycoproteins. It is compatible with Agilent’s AdvanceBio Glycan Mapping workflow, including HILIC UHPLC and CE-LIF systems. The standard also supports cross-platform method transfer and robustness studies, enhancing confidence in glycan structural assignments in regulatory submissions. For optimal results, pair with other AdvanceBio N-glycan standards and kits, such as the AdvanceBio Gly-X line, to enable comprehensive characterization across multiple analytical platforms. This reference material is an essential tool for laboratories performing sensitive and reproducible N-glycan analyses.