Agilent, PL1580-3302, AdvanceBio SEC 1000 Å, 2.7 µm, 4.6x150mm

AdvanceBio SEC 1000 Å, 2.7 µm, 4.6x150mm. A size exclusion column for aggregate analysis of large biological molecules such as VLPs and large oligonucleotides.

Specifications:
Brand: AdvanceBio SEC
Guard Column: No
Hardware: SS
Inner Diameter (ID): 4.6 mm
Length: 150 mm
Maximum Temperature: 80 °C
Molecular Weight Lower Limit: 15000 Da
Molecular Weight Upper Limit: 10 MDa
Particle Size: 2.7 µm
Particle Type: Fully Porous
Phase: SEC
Pore Size: 1000 Å
Pressure Rating: 400 bar
Separation Mode: SFC
Shipping Solvent: Phosphate Buffer/0.02% Sodium azide
Storage Temp Conditions: Store at ambient temperature
pH Range: 2-8.5

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This high-performance size exclusion chromatography (SEC) column features a 1000 angstrom pore size and a particle size of 2.7 micrometers in a 4.6 x 150 millimeter format, offering exceptional resolution for protein, antibody, and aggregate analysis. Designed for analytical applications in biotech and pharmaceutical research, it supports the characterization, separation, and quantitation of monoclonal antibodies, biosimilars, and other biologic macromolecules. The robust polymer-based base material ensures excellent durability and reproducibility, supporting high-throughput workflows and consistent batch-to-batch results.

Ideally suited for the analysis of protein molecular weight and aggregation state, this column delivers reliable performance in quality control, formulation development, and stability studies. It is fully compatible with Agilent HPLC systems such as the 1260 Infinity II and 1290 Infinity II, and can be seamlessly integrated into existing workflows for high-throughput bioseparations. The uniform particle size ensures reduced backpressure and enhanced resolution, while minimizing sample carryover and providing excellent recovery for sensitive biomolecules. For extended analytical needs, it can be paired with complementary Agilent AdvanceBio columns, and is supported by a range of Agilent calibration standards and SEC mobile phases for optimal performance and data accuracy.