Agilent, PL1580-5325, AdvanceBio SEC 500 Å, 2.7 µm, 4.6x300mm

AdvanceBio SEC 500 Å, 2.7 µm, 4.6x300mm. A size exclusion column for aggregate analysis of large biological molecules such as AAVs, VLPs, and large oligonucleotides.

Specifications:
Brand: AdvanceBio SEC
Guard Column: No
Hardware: SS
Inner Diameter (ID): 4.6 mm
Length: 300 mm
Maximum Temperature: 80 °C
Molecular Weight Lower Limit: 5000 Da
Molecular Weight Upper Limit: 5 MDa
Particle Size: 2.7 µm
Particle Type: Fully Porous
Phase: SEC
Pore Size: 500 Å
Pressure Rating: 400 bar
Separation Mode: Size Exclusion (SEC)
Shipping Solvent: Phosphate Buffer/0.02% Sodium azide
Storage Temp Conditions: Store at ambient temperature
pH Range: 2-8.5

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The AdvanceBio SEC 500 Å, 2.7 µm, 4.6x300mm column is designed for high-resolution size exclusion chromatography, optimized for the characterization and analysis of biomolecules such as monoclonal antibodies, proteins, and aggregates. With a 500 angstrom pore size and 2.7 micron particle technology, this column delivers superior separation efficiency and sharp peak resolution, enabling accurate molecular weight determination and aggregate profiling in biopharmaceutical research and quality control. The robust silica-based packing ensures reproducible performance, high mechanical strength, and excellent column lifetime, supporting demanding workflows in analytical development and routine testing. Ideal for use with leading UHPLC and HPLC systems from Agilent and other major manufacturers, this column is compatible with aqueous and organic mobile phases, enhancing flexibility for various analytical protocols. It supports analytical workflows in upstream and downstream process development, formulation studies, and stability testing. Part of the AdvanceBio SEC portfolio, it can be paired with complementary products for comprehensive biotherapeutic characterization. The column’s scalable design and reliable performance make it an essential tool for laboratories requiring precise size-based separation of proteins, ensuring confidence in data quality and regulatory compliance throughout biopharmaceutical development and production.