Biolegend, 102728, APC/Cyanine7 anti-mouse CD38 Antibody, 100μg

CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.
100μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Mouse bone marrow pre-B cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with APC/Cyanine7 under optimal conditions.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Red Laser (633 nm)
Product Citations: He W, et al. 2023. Immunity. 2408:56. PubMed Rivas MA, et al. 2021. Nat Immunol. 22:240. PubMed Leung W, et al. 2022. Cancer Discov. 12:1782. PubMed Tunali G, et al. 2023. J Clin Invest. :. PubMed Turner JS et al. 2018. Cell reports. 25(6):1395-1403 . PubMed Stewart I et al. 2018. Immunity. 49(3):477-489 . PubMed Wu J, et al. 2020. Cell Reports. 31(1):107484. PubMed Wong R, et al. 2020. Immunity. 53(5):1078-1094.e7. PubMed Nguyen TKT, et al. 2020. Am J Pathol. 286:190. PubMed Venturutti L, et al. 2020. Cell. 182(2):297-316.e27. PubMed Ayala TS, et al. 2019. Sci Rep. 9:11447. PubMed Fraser C, et al. 2022. Nat Commun. 13:5789. PubMed Olson WJ, et al. 2019. Cell Rep. 28:2878. PubMed
RRID: AB_2616967 (BioLegend Cat. No. 102727) AB_2616968 (BioLegend Cat. No. 102728)
Structure: ADP-ribosyl hydrolase, 42 kD
Distribution: B cells, NK cells, T cell subset, brain, muscle, kidney
Function: Regulation of cellular activation/proliferation, adhesion, metabolism of cADPR and NAADP
Ligand/Receptor: CD31, hyaluronic acid
Antigen References: 1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Shubinsky G, et al. 1997. Immunity 7:315. 3. Cesano A, et al. 1998. J. Immunol. 160:1106. 4. Cockayne DA, et al. 1998. Blood 92:1324.
Gene ID: 12494
UniProt: View information about CD38 on UniProt.org
Clone: 90
Regulatory Status: RUO
Other Names: T10
Isotype: Rat IgG2a, κ