Biolegend, 111907, PE anti-mouse CD91 Antibody, 25μg

CD91, also known as LRP1, is a transmembrane endocytic and cell signaling protein that regulates diverse cellular functions in the brain, liver, kidney, lung, and vasculature. The alpha and beta chains of LRP1 form a transmembrane receptor on the plasma membrane that plays a role in receptor-mediated endocytosis and lipoprotein metabolism. LRP1 gene encodes a 4545 amino acid precursor protein that is processed in the trans-Golgi complex into the 505 kD. It is involved in phagocytosis of apoptotic cells and cellular liquid homeostasis, as well as the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin). CD91 is also essential to the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. CD91 acts as an alpha-2-macroglobulin receptor and TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread and is required for early embryonic development.
25μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration: 0.2 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Blue Laser (488 nm)Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID: AB_3683138 (BioLegend Cat. No. 111907) AB_3683138 (BioLegend Cat. No. 111908)
Structure: 505 kD with 4545 a.a.
Distribution: Tissue Distribution: brain, lung, adipose tissue, and reproductive system Cellular Distribution: plasma membrane, nucleus, cytosol, lysosome, and endosome
Function: Endocytosis, phagocytosis of apoptotic cells, cellular lipid homeostasis
Interaction: LRPAP1, TAU/MAPT
Ligand/Receptor: Alpha-2-macroglobulin receptor and TAU/MAPT receptor
Cell Type: Macrophages, Microglia, Oligodendrocytes
Biology Area: Cell Motility/Cytoskeleton/Structure, Immunology, Protein Trafficking and Clearance, Signal Transduction
Molecular Family: Apolipoproteins, Tumor Suppressors
Antigen References: Herz J, et al. 1992. Cell. 71:411-21. Jennifer N.R., et al. 2020. Natural. 580(7803):381.
Gene ID: 16971
UniProt: View information about CD91 on UniProt.org
Clone: W19299B
Regulatory Status: RUO
Other Names: LRP1, LDL Receptor Related Protein 1
Isotype: Rat IgG2b, κ
Q: What type of PE do you use in your conjugates?
A: We use R-PE in our conjugates.