Biolegend, 112402, Purified anti-mouse CD136 (Mst1r) Antibody, 100μg

Macrophage-stimulating 1 receptor (MST1R/RON) is a receptor protein kinase that transduce signals from the extracellular matrix into the cytoplasm by binding to the macrophage-stimulating protein (MSP). MST1R regulates various physiological processes including cell adhesion, motility, growth, and survival. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, it interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. RON plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than the MST1 ligand.
100μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: MST1R transfectants
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2936598 (BioLegend Cat. No. 112402)
Structure: The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35 kD (alpha) and 150 kD (beta) subunits
Distribution: Myeloid progenitor, monocytes, granulocytes, dendritic cells, mast cells
Function: Cell adhesion, motility, differentiation and host defense
Interaction: Macrophages, dendritic cells, granulocytes, hematopoietic stem and progenitors
Ligand/Receptor: MST1 ligand
Molecular Family: CD Molecules
Antigen References: Nikolaidis NM, et al. 2011. Innate Immun. 17:499–507. Bezerra JA, et al. 1993. Hepatology. 18:394–9.
Gene ID: 19882
UniProt: View information about CD136 on UniProt.org
Clone: S20018D
Regulatory Status: RUO
Other Names: MSP receptor, CD136, RON, STK
Isotype: Rat IgG1, κ