Biolegend, 143819, PE/Fire™ 700 anti-mouse CD39 Antibody, 25μg

CD39, nucleoside triphosphate diphosphohydrolase-1 (NTPDase 1), is an ectoenzyme that degrades ATP to AMP. It is a member of the ectonucleoside triphosphate dihydrolases (E-NTPDases), which are involved in regulation of extracellular nucleotide catabolism and controlling the extracellular nucleoside triphosphate pool (NTP). CD39 is the dominant member of this family in the immune system, and is involved in suppression of inflammation and control of platelet activation. CD39 is expressed on B cells, dendritic cells, and a subset of T cells, including regulatory T cells and memory T cells. The coordinated expression of CD39/CD73 on Tregs and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops.
25μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: CD39 cDNA expression vector
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography and conjugated with PE/Fire™ 700 under optimal conditions.
Concentration: 0.2 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. * PE/Fire™ 700 has a maximum excitation of 565 nm and a maximum emission of 695 nm.
Excitation Laser: Blue Laser (488 nm)Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID: AB_2927877 (BioLegend Cat. No. 143819) AB_2927877 (BioLegend Cat. No. 143820)
Structure: A member of ectonucleoside triphosphate dihydrolases (E-NTPDases), an ectoenzyme that degrades ATP to AMP
Distribution: B cells, dendritic cells, and a subset of T cells
Function: Involved in suppression of inflammation and control of platelet activation; coordinated expression of CD39/CD73 on Tregs and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops
Interaction: Proteolysis of amyloid precursor protein (APP)
Cell Type: B cells, Dendritic cells, T cells, Tregs
Biology Area: Immunology
Molecular Family: CD Molecules
Antigen References: 1. Borsellino G, et al. 2007. Blood 110:1225. 2. Deaglio S, et al. 2007. J. Exp. Med. 204:1257. 3. Bynoe MS, et al. 2008. Trends Immunol. 29:99. 4. Ndhlovu LC, et al. 2010. Eur. J. Immunol. 40:134.
Gene ID: 12495
UniProt: View information about CD39 on UniProt.org
Clone: Duha59
Regulatory Status: RUO
Other Names: Entpd1, NTPDase1
Isotype: Rat IgG2a, κ