Biolegend, 147801, Purified anti-mouse CD209B Antibody, 25μg

CD209B, also known as SIGN-R1, is a mouse C-type lectin receptor predominantly expressed on macrophages in the spleen marginal zone and lymph nodes medulla. CD209B is a mouse homolog of human CD209/DC-SIGN and is involved in innate immune response. CD209B mediates the recognition and uptake of pathogen products, such as lipopolysaccharides (LPS), pneumococcal polysaccharides, and dextrans. CD209B has been demonstrated to facilitate the clearance of encapsulated pneumococcus by directly binding to C1q and activating complement through an immunoglobulin independent pathway.
25μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Partial mouse CD209B recombinant protein (74-325 aa)
Formulation: This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: Affinity purified.
Concentration: 0.5 mg/ml
Storage & Handling: Upon receipt, store undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2563445 (BioLegend Cat. No. 147801)
Structure: 325 amino acids, predicted molecular weight of 37 kD; single-pass type II membrane protein containing a C-type lectin domain.
Function: CD209B is a C-type lectin receptor, mediating the recognition of various bacteria and viruses during innate immue response.
Ligand/Receptor: CD209B binds to microbial polysaccharides and is a receptor for ICAM-3.
Molecular Family: CD Molecules
Antigen References: 1. Zhou Y, et al. 2010. Nat. Med. 16:1128. 2. Saunders SP, et al. 2010. J. Immunol. 184:2627. 3. Silva-Martin N, et al. 2009. Acta. Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 65:1264. 4. Saunders SP, et al. 2009. Infect. Immun. 77:399. 5. Park JY, et al. 2009. Neurosci. Lett. 450:246. 6. Lanoue A, et al. J. Exp. Med. 200:1383.
Gene ID: 69165
UniProt: View information about CD209B on UniProt.org
Clone: 2C7B27
Regulatory Status: RUO
Other Names: CD209 antigen-like protein B, DC-SIGN-related protein 1 (DC-SIGNR1)
Isotype: Rat IgG2a, κ