Biolegend, 150902, Purified anti-mouse IL-23R Antibody, 100μg

IL-23R is a 72 kD protein that associates with IL-12RB1 to form a heterodimer. It is a ligand for IL-23 and stimulates T, NK and some myeloid cells.  It is necessary for generation of Th17 cells but is not required for maintenance of previously generated Th17 cells.  Expression of IL-23R or mutations in the IL23R gene has been associated with autoimmunity and may also be important in tumor biology.
100μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Partial mouse IL-23R recombinant protein (aa 24-374)
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.75 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Product Citations: Tsai CM, et al. 2019. J Innate Immun. 333:12. PubMed Noll J, et al. 2016. J Hepatol. 64:1147-1157. PubMed
RRID: AB_2566431 (BioLegend Cat. No. 150902)
Structure: 72 kD protein that associates with IL-12RB1 to form a heterodimer.
Function: Involved in IL-23A signaling.
Interaction: JAK2 and STAT3.
Ligand/Receptor: IL-23/IL23A.
Biology Area: Immunology
Molecular Family: Cytokine/Chemokine Receptors
Antigen References: 1. Parham C, et al. 2002. J. Immunol. 168:5699. 2. Schmechel S, et al. 2008. Inflamm. Bowel Dis. 14:204. 3. Harris TJ, et al. 2007. J. Immunol. 179:4313. 4. Zhang XY, et al. 2006. Immunogenetics 57:934. 5. Awasthi A, et al. 2009. J. Immunol. 182:5904.
Gene ID: 209590
UniProt: View information about IL-23R on UniProt.org
Clone: 12B2B64
Regulatory Status: RUO
Other Names: Interleukin 23 Receptor, IL-23 Receptor, IL-23R, IBD17
Isotype: Rat IgG2b, κ