Biolegend, 152708, Alexa Fluor® 594 anti-mouse Lypd8 Antibody, 100μg

Ly6/PLAUR domain containing 8 (Lypd8) is a 100-120 kD GPI-anchored glycoprotein and a member of the Ly6/PLAUR family. Lypd8 is highly expressed on epithelial cells from intestinal lumen, where it prevents bacterial invasion by inhibiting bacterial motility by binding to flagella.
100μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Mouse Lypd8-transfected cells.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: IHC-F - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunohistochemical staining on frozen tissue sections. For immunohistochemistry, a concentration of 5 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses
Application Notes: This clone does not recognize Lypd8 from BALB/c mice.
Application References(PubMed link indicates BioLegend citation): Okumura R, et al. 2016. Nature 532:117.
RRID: AB_2721384 (BioLegend Cat. No. 152707) AB_2721385 (BioLegend Cat. No. 152708)
Structure: GPI-anchored, glycoprotein, 100-120 kD.
Distribution: Epitelials cells in cecum and large intestine.
Function: Inhibits bacterial motility by binding to flagella.
Cell Type: Epithelial cells
Biology Area: Immunology, Innate Immunity
Antigen References: 1. Okumura R, et al. 2016. Nature 532:117. 2. Loughner CL, et al. 2016. Hum. Genomics 10:10.
Gene ID: 70163
UniProt: View information about Lypd8 on UniProt.org
Clone: SA025A4
Regulatory Status: RUO
Other Names: Ly6/PLAUR domain containing 8
Isotype: Mouse IgG1, κ