Biolegend, 160105, PE anti-mouse CD192 (CCR2) Recombinant Antibody, 25μg

CD192, also known as CCR2, is a 42 kD G-protein coupled receptor that is associated with bone marrow homeostasis. Specifically, CD192 mediates monocyte chemotaxis and acts as a receptor for monocyte chemoattractant protein 1 (MCP-1). CD192 is primarily expressed on monocytes and macrophages, with some expression on basophils. It is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis and cancer.
25μg
Verified Reactivity: Mouse
Antibody Type: Recombinant
Host Species: Rat
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration: 0.2 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Blue Laser (488 nm)Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes: This clone binds to CD192, also known as CCR2, in mouse. This recombinant antibody clone is derived from clone SA203G11.
Product Citations: Kim AB, et al. 2024. JCI Insight. :9. PubMed
RRID: AB_2876565 (BioLegend Cat. No. 160105) AB_2876565 (BioLegend Cat. No. 160106)
Structure: G-protein-coupled receptor, 7-transmembrane protein, 42 kD.
Distribution: Monocytes/macrophages and basophils
Function: Mediator of monocyte chemotaxis and bone marrow homeostasis
Ligand/Receptor: MCP-1, Ccl2, Ccl7, and Ccl13
Cell Type: Basophils, Macrophages, Monocytes
Biology Area: Immunology
Molecular Family: CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References: 1. Mack M, et al. 2001. J. Immunol. 166:4697. 2. Dutta P, et al. 2015. Cell Stem Cell. 16:477. 3. Li L, et al. 2008. Kidney Int. 74:1526.
Gene ID: 12772
UniProt: View information about CD192 on UniProt.org
Clone: QA18A56
Regulatory Status: RUO
Other Names: C-C motif chemokine receptor 2, CD192
Isotype: Rat IgG2b, κ
Q: What type of PE do you use in your conjugates?
A: We use R-PE in our conjugates.