Biolegend, 161302, Purified anti-mouse PD-1H (VISTA) Antibody, 100μg

PD-1H, also known as VISTA, is a 309 aa type I transmembrane protein, composed of seven exons. PD-1H has one Ig-V like domain, and its sequence is similar to the Ig-V domains of the members of CD28 and B7 families. PD-1H is expressed by a subset of T cells, macrophages, dendritic cells, neutrophils, and NK cells. It has been proposed that PD-1H can be useful to modulate the host immune response to allogeneic transplants.
100μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Recombinant mouse VISTA
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: IHC-F - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunohistochemical staining on frozen tissue sections. For immunohistochemistry, a concentration range of 5.0 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2876577 (BioLegend Cat. No. 161302)
Structure: Type I transmembrane protein, member of the CD28 family
Distribution: Macrophages, dendritic cells, neutrophils, NK cells, naïve and activated T cells
Function: Negative regulator of the immune response
Interaction: Dendritic cells, Macrophages, Neutrophils, NK cells, T cells
Cell Type: Dendritic cells, Macrophages, Neutrophils, NK cells, T cells
Biology Area: Immunology
Antigen References: Flies DB, et al. 2011. J Immunol. 187:1537-41. Wang Li, et al. 2011. J Exp Med. 208:577-92.
Gene ID: 74048
UniProt: View information about PD-1H on UniProt.org
Clone: A17207D
Regulatory Status: RUO
Other Names: PD-1 homolog, Dies1, B7-H5
Isotype: Rat IgG2a, κ