Biolegend, 161402, Purified anti-mouse CD20 Recombinant Antibody, 500μg

CD20 is a 33-37 kD protein, a member of the MS4A family, with four transmembrane spanning regions that present as a homo-oligomeric complexes in the cell surface when associating with MHC class I and II, CD53, CD81, and CD82. CD20 is expressed on B cells and a subset of T cells, but not on plasma cells. CD20 regulates B-cell activation and proliferation. Its ligation promotes transmembrane Ca2+ trafficking. CD20 is an important therapeutic target in the treatment of B cell lymphomas and leukemias.
500μg
Verified Reactivity: Mouse
Antibody Type: Recombinant
Host Species: Mouse
Immunogen: Mouse CD20 transfected cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: This recombinant antibody clone is derived from clone SA271G2.
RRID: AB_2890726 (BioLegend Cat. No. 161402)
Structure: Member of the MS4A family, four transmembrane spanning regions, three isoforms of 37, 35, and 37 kD, depending on the phosphorylation degree.
Distribution: B cells and a subset of T cells
Function: Regulates B-cell activation and proliferation
Interaction: Associates with MHC class I and II, CD53, CD81, and CD82
Antigen References: 1. Morsy DE, et al. 2013. J. Immunol. 191:3112. 2. Pang X, et al. 2017. Hum Gene Ther. 28(2):216-225. 3. Uchida J, et al. 2004. Int Immunol. 16(1):119-29
Gene ID: 12482
UniProt: View information about CD20 on UniProt.org
Clone: QA18A73
Regulatory Status: RUO
Other Names: Ms4a1, Ly-44
Isotype: Mouse IgG2a, κ