Biolegend, 165302, Purified anti-mouse IL-33Rα (IL1RL1, ST2) Antibody, 100μg

IL-33Rα, also known as ST2 or IL-1RL1, is a member of the Toll/IL-1 receptor family. It binds IL-33 and is structurally similar to IL-1R1. Two forms of the protein exist: a soluble form known as ST2 and a membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is expressed by serum-stimulated fibroblasts. Signaling through IL1RL1 drives cytokine production in mast cells, basophils, eosinophils, invariant NKT and NK cells, Th2 lymphocytes, and type 2 innate immune cells. IL-33 signaling is required for maintaining the suppressive function of regulatory T cells.
100μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Recombinant mouse IL-33Rα, AA 27-342
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2922503 (BioLegend Cat. No. 165302)
Structure: Single-pass type I membrane protein
Distribution: Th2 lymphocytes, mast cells, fibroblasts
Function: Following interaction with IL-33, it recruits MyD88, Irak1, Irak4 and Traf6 followed by phosphorylation of the MAP/ERK pathway
Interaction: Interacts with MyD88, Irak1, Irak4 and Traf6
Ligand/Receptor: IL-33
Cell Type: Fibroblasts, Mast cells, Th2
Biology Area: Immunology, Innate Immunity
Molecular Family: Cytokine/Chemokine Receptors
Antigen References: Yanagisawa K, et al. 1993. FEBS Lett. 318:83-7. Schmitt E, et al. 1990. Cytokine. 2:407-15. Yanagisawa K, et al. 1992. FEBS Lett. 302:51-3. Takagi T, et al. 1993. Biochim Biophys Acta. 1178:194-200.
Gene ID: 9173
UniProt: View information about IL-33Ralpha on UniProt.org
Clone: W17243F
Regulatory Status: RUO
Other Names: IL-33R, ST2, IL-1RL1
Isotype: Rat IgG2a, κ