Biolegend, 251102, Purified anti-rat CD161 Recombinant Antibody, 100μg

QA19A15 recombinant monoclonal antibody recognizes the rat killer cell lectin-like receptor subfamily B member1 protein, also known as CD161. CD161 is expressed on rat NK cells and T cell subpopulations, activated monocytes, and dendritic cells. CD161 molecules are C-type lectin-like receptors that can either activate (CD161a) or inhibit (CD161b) effector leucocyte responses, eg, cytotoxicity or cytokine production, against target cells which express C-type lectin-like related (Clr) molecules.
100μg
Verified Reactivity: Rat
Antibody Type: Recombinant
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2894684 (BioLegend Cat. No. 251102)
Structure: CD161 is a 233 amino acid ~60 kDa homodimers, type II single pass protein containing a single C-type lectin domain.
Distribution: NK cells, subset of T cells, dendritic cells, activated monocytes.
Function: NKR-P1a is a NK cell-activating receptor; NKR-P1b is a NK cell-inhibitory receptor.
Ligand/Receptor: LLT1-ligand lectin like transcript 1; KLR-killer cell lectin like receptor.
Cell Type: Dendritic cells, Monocytes, NK cells, T cells
Biology Area: Cell Biology, Immunology, Innate Immunity, Signal Transduction
Molecular Family: CD Molecules
Antigen References: Chambers WH, et al. 1989. J Exp Med. 169:1373. Brink M, et al. 1990. J Exp Med. 171:197. Li J, et al. 2003. Int Immunol. 15:411.
Gene ID: 362443
UniProt: View information about CD161 on UniProt.org
Clone: QA19A15
Regulatory Status: RUO
Other Names: CD161, NKR-P1, CD161a/CD161b, NKR-P1a/KLRB1a
Isotype: Mouse IgG1, κ