Biolegend, 300816, KIRAVIA Blue 520™ anti-human CD137 (4-1BB) Antibody, 100tests

CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.
100tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant human CD137-Fc
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with KIRAVIA Blue 520™ under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * KIRAVIA Blue 520™ has an excitation maximum of 495 nm, and a maximum emission of 520 nm. KIRAVIA Blue™ 520 is a trademark of Sony. This product is subject to proprietary rights of Sony and is made and sold under license from Sony Corporation. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.Sony and the Sony logo are registered trademarks of Sony Corporation.
Excitation Laser: Blue Laser (488 nm)
RRID: AB_2928000 (BioLegend Cat. No. 300815) AB_2928000 (BioLegend Cat. No. 300816)
Structure: TNFR superfamily, type I transmembrane protein, 30 kD
Distribution: Activated T cells
Function: T cell costimulation
Ligand/Receptor: 4-1BB ligand (CD137L)
Cell Type: Lymphocytes, NK cells, NKT cells, T cells
Biology Area: Costimulatory Molecules, Immuno-Oncology, Immunology, Signal Transduction
Molecular Family: CD Molecules
Antigen References: Gruss HJ & Dower SK. 1995. Blood. 85:3378-404. Sica G & Chen L. 2000. Adv Exp Med Biol. 465:355-62. Alderson MR, et al. 1994. Eur J Immunol. 24:2219-27. Schwarz H, et al. 1996. Blood 87:2839-45.
Gene ID: 3604
UniProt: View information about CD137 on UniProt.org
Clone: S18014C
Regulatory Status: RUO
Other Names: 4-1BB, ILA, CDw137, TNFRSF9
Isotype: Mouse IgG1, κ