Biolegend, 302703, FITC anti-human CD26 Antibody, 25tests

CD26 is a 110 kD type II membrane protein also known as ADA-binding protein and dipeptidyl peptidase IV (DPPIV). It is a member of the peptidase and ectoenzyme family. CD26 is expressed on the membrane of mature thymocytes, T lymphocytes (upregulated upon activation), B cells, NK cells, and macrophages. CD26 cleaves off N-terminal X-Pro and X-Ala dipeptides from polypeptides. It plays an integral role as a costimulatory molecule in T cell activation. CD26 may interact with extracellular matrix proteins such as fibronectin or collagen, CD45 and ADA.
25tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser: Blue Laser (488 nm)
Application References(PubMed link indicates BioLegend citation): Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Press. London. Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York.
Product Citations: Fu H, et al. 2023. Regen Ther. 22:7. PubMed Musvosvi M, et al. 2023. Nat Med. 29:258. PubMed Gur C, et al. 2022. Cell. 185:1373. PubMed Wragg KM, et al. 2020. Cell Reports. 31(11):107773. PubMed Xin Y, et al. 2017. Exp Cell Res. 10.1016/j.yexcr.2017.04.021. PubMed Tardif V, et al. 2019. Nat Commun. 10:823. PubMed Park J, et al. 2016. Proc Natl Acad Sci U S A. 113: 4482-4487. PubMed Lo ST, et al. 2021. Mol Imaging Biol. 23:230. PubMed Borrelli MR, et al. 2020. Aesthet Surg J. 369:40. PubMed Pfaender S, et al. 2020. Nat Microbiol. 1.131944444. PubMed Stoyanova T, et al. 2013. Proc Natl Acad Sci U S A. 110:20111. PubMed Khuzwayo S, et al. 2021. Front Immunol. 12:631410. PubMed Henry G, et al. 2017. Prostate. 77:1344. PubMed Angueira AR, et al. 2021. Nat Metab. 3:469. PubMed Jiang J, et al. 2016. Sci Rep. 6: 32320. PubMed
RRID: AB_314288 (BioLegend Cat. No. 302704)
Structure: Peptidases and ectoenzyme families, type II glycoprotein, 110 kD
Distribution: Thymocyte subset, memory T cells, B cells, NK cells, epithelial cells, macrophages
Function: Dipeptidyl peptidase, T cell costimulation, HIV entry
Ligand/Receptor: Adenosine-deaminase, collagen
Cell Type: B cells, Epithelial cells, Macrophages, NK cells, T cells, Thymocytes
Biology Area: Costimulatory Molecules, Immunology
Molecular Family: CD Molecules
Antigen References: 1. Kameoka J, et al. 1993. Science 261:466. 2. Dang N, et al. 1990. J. Exp. Med. 172:649.
Gene ID: 1803
UniProt: View information about CD26 on UniProt.org
Clone: BA5b
Regulatory Status: RUO
Workshop: VI N-L078
Other Names: ADA-binding protein, DPP IV ectoenzyme, EC 3.4.14.5, DPP4
Isotype: Mouse IgG2a, κ