Biolegend, 306852, Purified anti-human CD30 Antibody, 100μg

CD30, also known as Ki-1 antigen, lymphoid activation antigen CD30, and tumor necrosis factor receptor superfamily member 8, is a type I transmembrane receptor that contains four TNF receptor domains with an approximate molecular weight of 64 kD. CD30 is highly expressed on Hodgkins and Reed-Sternberg cells as well as activated, but not resting, T and B cells. CD30 has been shown to interact with a number of proteins including TRAF1, TRAF2, TRAF3, TRAF5, NPM-ALK, TRAF-interacting protein, and CD30 ligand (CD153). Signaling through CD30 is thought to limit the proliferative potential of autoreactive CD8 effector T cells and protect against autoimmunity.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant Human CD30
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_3106029 (BioLegend Cat. No. 306852)
Structure: Type I transmembrane receptor and member of the TNF receptor superfamily that contains 4 TNF receptor domains; predicted molecular weight approximately 64 kD.
Distribution: Highly expressed on Hodgkins and Reed-Sternberg cells and activated, but not resting, T cells and B cells.
Function: Signaling through CD30 is thought to limit the proliferative potential of autoreactive CD8 effector T cells and protect against autoimmunity.
Interaction: TRAF1, TRAF2, TRAF3, TRAF5, NPM-ALK, TRAF-interacting protein, CD30 ligand (CD153)
Ligand/Receptor: CD30 Ligand (CD153)
Cell Type: B cells, Embryonic Stem Cells, Tregs
Biology Area: Immunology, Stem Cells
Molecular Family: CD Molecules
Antigen References: Durkop H, et al. 1992. Cell. 68:421-7. Aizawa S, et al. 1997. J Biol Chem. 272:2042-5. Stein H, et al. 1982. Int J Cancer. 30:445-59.
Gene ID: 943
UniProt: View information about CD30 on UniProt.org
Clone: A20146B
Regulatory Status: RUO
Other Names: Ber-H2, Ki-1, TNFRSF8
Isotype: Mouse IgG2b, κ