Biolegend, 315107, Purified anti-human CD39 Antibody, 100μg

Human CD39 is an integral membrane protein with two transmembrane domains. It exists as a homotetramer. Expression of CD39 is found on activated lymphocytes, a subset of T cells and B cells, and dendritic cells with weak staining on monocytes and granulocytes. CD39 and CD73 have been found on regulatory T cells, specifically the effector/memory-like. CD39 can hydrolyze both nucleoside triphosphates and diphosphates. CD39 is the dominant ectonucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs). CD39 has intrinsic ecto-ATPase activity. Expression of CD39 is induced on T cells and increased on B cells as a late activation antigen.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human CD39 transfected cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested ICC - Verified
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. For immunocytochemistry, a concentration range of 1.0 - 2.5 μg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_3683330 (BioLegend Cat. No. 315107)
Structure: Multi-pass membrane protein
Distribution: Plasma membrane, Caveola
Function: ATP hydrolysis, ATP binding, Hydrolase
Interaction: Activated lymphocytes
Cell Type: B cells, Dendritic cells, Lymphocytes, T cells, Tregs
Biology Area: Immunology
Molecular Family: CD Molecules
Antigen References: Maliszewski CR, et al. 1994. J Immunol. 153:3574-3583. Kaczmarek E, et al. 1996. J Biol Chem. 271:33116-33122. Jiang X, et al. 2023. Front Immunol. 14:1110325-1110325. Timperi E, et al. 2021. Int J Mol Sci. 22:8068-8068. Mitra A, et al. 2023. Clin Cancer Res. 29:4242-4255.
Gene ID: 953
UniProt: View information about CD39 on UniProt.org
Clone: S23003F
Regulatory Status: RUO
Other Names: ENTPD1, ATPDase, NTPDase-1, SPG64, ectonucleoside triphosphate diphosphohydrolase 1
Isotype: Mouse IgG1, κ