Biolegend, 315905, Purified anti-human CD102 (ICAM-2) Antibody, 100μg

CD102, also known as Intercellular Adhesion Molecule-2, or ICAM-2, is a 55 kD type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily. CD102 is constitutively expressed on vascular endothelial cells, some lymphocytes, monocytes, and platelets. CD102 is thought to be involved in lymphocyte recirculation and in costimulation of immune responses. CD102 is a counter receptor of LFA-1 (CD11a/CD18), DC-SIGN, and MAC-1.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Human CD102 (ICAM-2) recombinant protein fragment
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: Flow cytometry testing showed that clone W22038F can block the binding of clone CBR-IC2/2 on target cells. Flow cytometry testing showed that clone W22038F does not affect the binding of clone W22039A on target cells.
RRID: AB_3675044 (BioLegend Cat. No. 315905)
Structure: 55 kD type I transmembrane glycoprotein, Ig superfamily
Distribution: Vascular endothelial cells, lymphocytes, monocytes, platelets
Function: Adhesion, costimulation
Ligand/Receptor: LFA-1, DC-SIGN, MAC-1
Cell Type: Epithelial cells, Lymphocytes, Monocytes, Platelets
Biology Area: Immunology
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: Weber KSC, et al. 2004. Inflammation. 28:177-88. Barclay A, et al. 1997. The Leukoycte Antigen FactsbookAcademic Press. Casasnovas JM, et al. 1999. P Natl Acad Sci. USA. 96:3017. Diamonds MS, et al. 1990. J Cell Biol. 111:3129-39.
Gene ID: 3384
UniProt: View information about CD102 on UniProt.org
Clone: W22038F
Regulatory Status: RUO
Other Names: Intercellular Adhesion Molecule-2, ICAM-2
Isotype: Rat IgG2a, κ