Biolegend, 324504, Alexa Fluor® 647 anti-human IgD Antibody, 100μg

IgD, a member of the immunoglobulin (Ig) family, is expressed in naïve B cells. It has 3 Ig-like domains and exists in a transmembrane and a soluble form. In general, IgD is not secreted and usually its expression is lost after the Ig isotype switch. After antigen binding, IgD signals through the CD79a/CD79b (Igα/Igβ) heterodimer, resulting in the activation of the B cell.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Full length human IgD recombinant protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: IHC-P - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration of 10.0 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses
Excitation Laser: Red Laser (633 nm)
RRID: AB_3097334 (BioLegend Cat. No. 324503) AB_3097334 (BioLegend Cat. No. 324504)
Structure: Exists in a transmembranal and a soluble form
Distribution: Naïve B cells
Function: Antigen binding, B cell activation
Interaction: The CD79a/CD79b heterodimer
Molecular Family: Immune Checkpoint Receptors, Innate Immune Signaling
Antigen References: Geisberger R, et al. 2006. Immunology 118:429-37. Weller S, et al. 2005. Eur J Immunol. 35:2789-92. Brandtzaeg P & Johansen FE. 2005. Immunol Rev. 206:32-63.
Gene ID: 3495
UniProt: View information about IgD on UniProt.org
Clone: W18340A
Regulatory Status: RUO
Other Names: Ig delta chain C region
Isotype: Rat IgG2a, κ