Biolegend, 326605, PE anti-human CD344 (Frizzled-4) Antibody, 25tests

CD344 is a member of the Frizzled family, known as Frizzled-4 (Fz4, FZD4, hFz4, or FzE4). Ten frizzled member have been identified in humans. Human FZD4 gene has been mapped to chromosome 11q14-q21. FZD4 is a 48-53 kD seven transmembrane G-protein-coupled receptor (GPCR), a receptor for Wnt proteins and norrie. It is involved in the activation of Wnt/β-catenin pathway (canonic Wnt signaling). FZD4 is a neuronal stem cell marker and is also expressed on fetal neuronal progenitor cells and neuronal intestinal cells. Kidney, lung, brain and liver express abundant of FZD4. It has been reported that FZD4 controls retinal and inner ear angiogenesis, participates in the regulation of embryonic development, tissue and cell polarization and proliferation.
25tests
Verified Reactivity: Human
Reported Reactivity: African Green, Cynomolgus
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: WERI-RB-1 retinoblastoma cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser: Blue Laser (488 nm)Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID: AB_2109244 (BioLegend Cat. No. 326605) AB_2109243 (BioLegend Cat. No. 326606)
Structure: Frizzled family, seven transmenbrane G-protein-coupled receptor, 48-53 kD
Distribution: Kidney, lung, brain, liver, neuronal stem cells, fetal neuronal progenitor cells and neuronal intestinal cells
Function: Embryonic development, tissue/cell polarization and proliferation
Ligand/Receptor: Norrie, Wnt proteins
Biology Area: Angiogenesis, Cell Biology, Immunology
Molecular Family: CD Molecules
Antigen References: 1. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers Wiley-Liss A John Wiley & Sons Inc, Publication 2. Kirikoshi H, et al. 1999. Biochem. Biophys. Res. Commun. 264:955. 3. Smallwood PM, et al. 2007. J. Biol. Chem. 282:4057.
Gene ID: 8322
UniProt: View information about CD344 on UniProt.org
Clone: CH3A4A7
Regulatory Status: RUO
Other Names: Frizzled-4 receptor, Frizzled-4, Fz4, FZD4, FzE4, hFz4, FEVR, EVR1
Isotype: Mouse IgG1, κ
Q: What type of PE do you use in your conjugates?
A: We use R-PE in our conjugates.