Biolegend, 342110, PE/Cyanine7 anti-human CD82 Antibody, 100tests

CD82 is a 45-90 kD type III tetraspan membrane protein which is encoded by the KAI1 gene. A member of the 4-span transmembrane protein superfamily (TM4SF) CD82 forms a complex with CD37, CD53, CD81, ECM and MHC molecules. CD82 is expressed on monocytes, granulocytes, lymphocytes, epithelial cells, endothelial cells, and fibroblasts and plays a role in signal transduction and adhesion. It has been suggested CD82 functions as a tumor suppressor as loss of expression has been found to promote tumor metastasis.
100tests
Verified Reactivity: Human
Reported Reactivity: African Green, Baboon, Cynomolgus
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser: Blue Laser (488 nm)Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID: AB_2750122 (BioLegend Cat. No. 342109) AB_2750123 (BioLegend Cat. No. 342110)
Structure: Type III tetraspan membrane protein, 45-90 kD, complexed with CD37, CD53, CD81, ECM and MHC molecules, 4-span transmembrane protein superfamily (TM4SF)
Distribution: Monocytes, granulocytes,lymphocytes, epithelial cells, endothelial cells, fibroblasts
Function: Signal transduction, adhesion, tumor metastasis suppressor
Ligand/Receptor: KITENIN
Cell Type: Basophils, Endothelial cells, Epithelial cells, Granulocytes, Lymphocytes, Monocytes
Biology Area: Immunology
Molecular Family: CD Molecules
Antigen References: 1. Miranti CK. 2009. Cell. Signal. 21:196 2. Abe M, et al. 2008. 266:163 3. Lee JH et al. 2004. Cancer Res. 64:4235 4. Lagaudriere-Gesbert C, et al. 1997. J. Immunol. 158:2790
Gene ID: 3732
UniProt: View information about CD82 on UniProt.org
Clone: ASL-24
Regulatory Status: RUO
Other Names: KAI1, C33, R2, 4F9, IA4
Isotype: Mouse IgG1, κ