Biolegend, 360202, Purified anti-human CD368 (CLEC4D) Antibody, 100μg

CD368 (CLEC4D), also known as CLEC6, is a 30 kD single pass type II transmembrane protein and member of the C-type lectin-like domain (CTLD) superfamily. CLEC4D is an endocytic receptor, probably involved in antigen presentation, cell adhesion, and cell signaling. CLEC4D is expressed by macrophages, monocytes, neutrophils, and a subset of dendritic cells and is upregulated by IL-6, IL-10, TNF-α, and IFN-γ.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: CLEC4D ectodomain:IgG Fc fusion protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality testedICC - Verified
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2562508 (BioLegend Cat. No. 360202)
Structure: Member of the C-type lectin-like domain (CTLD) superfamily, single pass type II transmembrane protein, 30 kD
Distribution: Macrophages, monocytes, neutrophils, subset of dendritic cells; low expression in peripheral blood lymphocytes
Function: Endocytic receptor, probably involved in antigen presentation, cell adhesion, and cell signaling
Cell Type: Dendritic cells, Macrophages, Monocytes, Neutrophils
Biology Area: Immunology, Innate Immunity
Molecular Family: CD Molecules
Antigen References: 1. Zhu LL, et al. 2013. Immunity 39:11. 2. Graham LM, et al. 2012. J. Biol. Chem. 287:25964. 3. Arce I, et al. 2004. Eur. J. Immunol. 34:210.
Gene ID: 338339
UniProt: View information about CD368 on UniProt.org
Clone: 9B9
Regulatory Status: RUO
Workshop: HCDM listed
Other Names: C-type lectin domain family 4 member D, CLEC6, CLECSF8, MCL, MPCL, Dectin-3, CD368
Isotype: Mouse IgG2b, κ