Biolegend, 362005, APC anti-human CD130 (gp130) Antibody, 25tests

CD130, also known as gp130 (glycoprotein 130), IL6ST (IL-6-receptor-associated signal transducer), or common β chain, is a member of the hematopoietic cytokine receptor family. CD130 is a common subunit associated with the receptors for several cytokines, such as IL-6, IL-11, Oncostatin M (OSM), CNTF (ciliary neurotrophic factor), CT-1, Neuropoietin (NP), and IL-27. CD130 participates in the JAK-STAT signaling pathway and is expressed on T cells, activated B cells, monocytes, plasma cells, and endothelial or epithelial cells.
25tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: GP130 (23-619aa) recombinant protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser: Red Laser (633 nm)
Product Citations: Silvin A, et al. 2020. Cell. 182:1401. PubMed Siepe DH, et al. 2022. Elife. 11:. PubMed Nunes-Santos CJ, et al. 2023. Nat Commun. 14:3708. PubMed Moya-Jódar M, et al. 2023. Stem Cell Reports. 18:64. PubMed Baryawno N et al. 2019. Cell. 177(7):1915-1932 . PubMed Saga R, et al. 2019. Oncol Lett. 17:3555. PubMed Wilmes S, et al. 2021. Elife. 10:. PubMed Hara T, et al. 2021. Cancer Cell. 39(6):779-792.e11. PubMed
RRID: AB_2563403 (BioLegend Cat. No. 362005) AB_2563404 (BioLegend Cat. No. 362006)
Structure: 130 kD type I transmembrane glycoprotein.
Distribution: T cells, activated B cells, monocytes, plasma cells, endothelial cells and epithelial cells.
Function: Common β subunit of IL-6 receptor family, plays a role in signal transduction.
Ligand/Receptor: IL-6, IL-11, OSM, CNTF, CT-1, NP, IL-27.
Cell Type: B cells, Endothelial cells, Epithelial cells, Monocytes, Plasma cells, T cells
Biology Area: Immunology
Molecular Family: CD Molecules
Antigen References: 1. Arzt E, et al. 2001. J. Clin. Invest. 108:1729. 2. Bravo J, et al. 2000. EMBO J. 19:2399. 3. Wang XJ, et al. 1998. Blood 91:3308. 4. Hibi. M, et al. 1990. Cell. 63:1149. 5. Schlossman S, et al. 1995. ed. Leukocyte Typing V. New York. Oxford University Press.
Gene ID: 3572
UniProt: View information about CD130 on UniProt.org
Clone: 2E1B02
Regulatory Status: RUO
Other Names: GP130, GP-130, IL6ST, IL-6Rβ, Oncostatin M Receptor, Oncostatin-M receptor subunit alpha
Isotype: Mouse IgG2a, κ