Biolegend, 366102, Purified anti-human EMR3 Recombinant Antibody, 100μg

EMR3 is a member of the EGF-7 transmembrane (TM7) adhesion GPCR family. It is predominantly expressed on granulocytes, neutrophils, monocytes, and macrophages, and at lower levels on mature myeloid cells and dendritic cells. EMR3 is absent on lymphocytes, hematopoietic stem cells and myeloid progenitors. Studies suggest that the EMR3 molecule is upregulated during late stages of neutrophil differentiation and is a marker for terminally differentiated cells. EMR3 may play a role in myeloid-myeloid interactions during immune and inflammatory responses.
100μg
Verified Reactivity: Human
Antibody Type: Recombinant
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2904400 (BioLegend Cat. No. 366102)
Structure: EGF-like domain, 7-transmembrane
Distribution: Granulocytes, neutrophils, monocytes, macrophages, dendritic cells
Function: Adhesion, myeloid-myeloid cell interaction
Cell Type: Dendritic cells, Granulocytes, Monocytes, Neutrophils
Biology Area: Adaptive Immunity, Cell Adhesion, Immunology, Innate Immunity
Molecular Family: Adhesion Molecules, GPCR
Antigen References: Matmati M. et al. 2007, J Leukoc Biol. 81:440-8. Stacey M, et al. 2001. J Biol Chem. 276:18863-70.
Gene ID: 84658
UniProt: View information about EMR3 on UniProt.org
Clone: QA20A59
Regulatory Status: RUO
Other Names: Adhesion G protein-coupled receptor E3; EGF module-containing mucin-like hormone receptor 3
Isotype: Mouse IgG1, κ