Biolegend, 366404, PE anti-human Dopamine Receptor D1 Antibody, 100tests

Dopamine receptors are a family of G protein-coupled receptors, which is composed of at least five (D1-D5) members. The D1 subtype is the most common receptor in the central nervous system. It is primarily expressed in caudate putamen in humans. This receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. It plays a role in neuronal growth and development along with behavioral responses. The D1 receptor also modulates D2-mediated events. There are two variants of this gene due to alternate transcription initiation sites.
100tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human DRD1-transfectants.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser: Blue Laser (488 nm)Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations: Gao A, et al. 2023. J Pharmacol Exp Ther. . PubMed Bellon A, et al. 2019. Front Mol Neurosci. 11:323. PubMed
RRID: AB_2565470 (BioLegend Cat. No. 366404)
Structure: G protein-coupled receptor.
Distribution: DRD1 Transfected cells.
Function: Stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases.
Ligand/Receptor: Dopamine.
Cell Type: Dopaminergic Neurons
Biology Area: Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Synaptic Biology
Molecular Family: CD Molecules, GPCR, Postsynaptic proteins
Antigen References: 1. Fresnoza S, et al. 2014. J. Neurosci. 34(7):2744. 2. Mizuta K, et al. 2013. Respir. Res. 14:89. 3. Zhu F, et al. 2013. PLoS One 8(8):e70805. 4. Levy F, et al. 2013. J. Child Adolesc. Psychopharmacol. 6:423.
Gene ID: 1812
UniProt: View information about Dopamine Receptor D1 on UniProt.org
Clone: L205G1
Regulatory Status: RUO
Other Names: DADR, DRD1A, DRD1
Isotype: Mouse IgG2b, κ
Q: What type of PE do you use in your conjugates?
A: We use R-PE in our conjugates.