Biolegend, 367302, Purified anti-human APCDD1 (DRAPC1) Antibody, 100μg

APCDD1 (adenomatosis polyposis coli down-regulated 1), also known as B7323, DRAPC1, or FP7019, is a 514 amino acid single-pass type I membrane protein. APCDD1 is expressed in the gastrointestinal tract, placental trophoblasts, and both epidermal and dermal compartments from human hair follicles. It is also weakly expressed in lymphoid tissues. APCDD1 has been reported to be directly regulated by the beta-catenin/ITF-2 complex and that its elevated expression promotes the proliferation of colonic epithelial cells. It is thought to function as a developmental target of the beta-catenin pathway and may play an important role in colorectal tumorigenesis. Recently, it was found to negatively regulate Wnt signaling in a cell-autonomous manner.
100μg
Verified Reactivity: Human
Reported Reactivity: Cynomolgus
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human APCDD1-His.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested ICC - Verified
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. For immunocytochemistry, a concentration of 10 µg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2565749 (BioLegend Cat. No. 367302)
Structure: 514 amino acid single-pass type I membrane protein.
Distribution: Gastrointestinal track and placental trophoblastis, epidermal and dermal compartments of the hair follicle, and weak expression in lymphoid tissues.
Function: May regulate a diversity of biological process controlled by Wnt signaling, regulated by beta-catenin/ITF-2 complex.
Interaction: Plays an important role in colorectal tumorigenesis.
Biology Area: Immunology
Molecular Family: CD Molecules
Antigen References: 1. Shimomura Y, et al. 2010. Nature 7291:1043. 2. Takahashi M, et al. 2002. Cancer Res. 20:5651.
Gene ID: 147495
UniProt: View information about APCDD1 on UniProt.org
Clone: 7.13
Regulatory Status: RUO
Other Names: Adenomatosis polyposis coli down-regulated 1, B7323, DRAPC1, P7019
Isotype: Mouse IgG2a, κ