Biolegend, 367702, Purified anti-human KLRG1 (MAFA) Antibody, 100μg

Killer cell lectin-like receptor subfamily G member 1 (KLRG1) is a 30 kD, type II membrane glycoprotein with one C-type lectin domain and one immunoreceptor tyrosine-based inhibititory motif (ITIM). KLRG1 is expressed by subsets of NK, effector and memory T cells. KLRG1 inhibits cell activation and proliferation, and is a marker of T cell senescence. Binding of KLRG1 to E-, N-, or R- cadherins blocks phosphorylation of Akt and increases the expression of cell cycle inhibitors.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human KLRG1-transfected cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Product Citations: Taft J, et al. 2021. Cell. 184(17):4447-4463.e20. PubMed Wei SC et al. 2017. Cell. 170(6):1120-1133 . PubMed Kondo H, et al. 2022. Front Immunol. 13:836923. PubMed Sanz–Ortega L, et al. 2019. Front Immunol. 1.85625. PubMed Sattler A, et al. 2021. Am J Transplant. 21:87. PubMed
RRID: AB_2632728 (BioLegend Cat. No. 367702)
Structure: Type II membrane glycoprotein, one C-type lectin domain, one ITIM, 30 kD.
Distribution: Subsets of NK, effector and memory T cells.
Function: Inhibits cell activation and proliferation, marker of T cell senescence.
Interaction: AKT
Ligand/Receptor: E-, N-, and R- cadherins
Cell Type: NK cells, T cells
Biology Area: Immunology, Innate Immunity
Antigen References: 1. Shi L, et al. 2014. J. Immunol. 192:649.
Gene ID: 10219
UniProt: View information about KLRG1 on UniProt.org
Clone: SA231A2
Regulatory Status: RUO
Other Names: CLEC15A, MAFA-L, MAFA-2F1, MAFA-LIKE, 2F1
Isotype: Mouse IgG2a, κ