Biolegend, 372305, APC anti-human CD217 Antibody, 25tests

Six interleukin-17 (IL-17)-family (IL-17A-IL-17F) and five IL-17 receptor (IL-17R)-family (IL-17RA-IL-17RE) members have been reported in mammalian cells. IL-17RA (known as IL-17R, IL-17AR, CD217) is a 128-158 kD type I transmembrane glycoprotein. IL-17R binds to IL-17A (also known as IL-17, and CTLA-8, is a hallmarker of Th17 cells) and IL-17F and mediates the proinflammatory signals through interaction with IL-17RC or IL-17RD. IL-17R has broad tissue distribution, including fibroblasts, epithelial cells, endothelial cells, stromal cells, B cells, T cells, NK cells, monocytes and granulocytes.
25tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: P3U1 cells stably transfected with CD217.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser: Red Laser (633 nm)
Product Citations: Knizkova D, et al. 2022. Nat Immunol. 23:1644. PubMed
RRID: AB_2632913 (BioLegend Cat. No. 372305) AB_2632914 (BioLegend Cat. No. 372306)
Structure: 128-158 kD type I single transmembrane glycoprotein, homodimer or heterodimer with IL-17RC, or associate with IL-17RD.
Distribution: Broad tissue distribution, including fibroblasts, epithelial cells, endothelial cells, stromal cells, B cells, T cells, NK cells, monocytes and granulocytes
Function: Binds IL-17 and mediate IL-17 induced inflammatory responses.
Ligand/Receptor: IL-17A, IL-17F.
Cell Type: Eosinophils, Neutrophils
Biology Area: Immunology
Molecular Family: CD Molecules
Antigen References: 1. Moseley TA, et al. 2003. Cytokine Growth Factor Rev. 14:155. 2. Rong Z, et al. 2009. Cell. Res. 19:208. 3. Toy D, et al. 2006. J. Immunol. 177:36.
Gene ID: 23765
UniProt: View information about CD217 on UniProt.org
Clone: W15177A
Regulatory Status: RUO
Other Names: IL-17R, IL-17RA, IL-17AR, IL-17 receptor
Isotype: Mouse IgG2a, κ