Biolegend, 373904, APC anti-human FcRL6 Antibody, 100tests

FcRL6, a member of Fc receptor-like family, does not bind Ig. It is expressed on cytotoxic NK and a subset of T cells (primarily CD8 + T cells).  Its expression level correlates with the differentiation state of these cells. This Type I transmembrane glycoprotein consists of three Ig-like domains on its extracellular and a consensus ITIM or non-canonical ITAM-like sequence on its cytoplasmic region. Patients with chronic lymphocytic leukemia show higher abundance of this receptor due to expansion of cytotoxic lymphocyte population.
100tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: BW5147 transduced with HA-tagged FcRL6
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Red Laser (633 nm)
Application References(PubMed link indicates BioLegend citation): Schreeder DM, et al. 2008. Eur. J. Immunol. 38:3159. (FC)
RRID: AB_2876702 (BioLegend Cat. No. 373903) AB_2876702 (BioLegend Cat. No. 373904)
Structure: Type I transmembrane glycoprotein, Ig gene superfamily
Distribution: NK, T subset
Cell Type: NK cells, T cells
Biology Area: Immunology
Molecular Family: Fc Receptors
Antigen References: 1. Davis RS. 2007. Annu. Rev. Immunol. 25:525. 2. Wilson TJ, et al. 2007. Blood 109:3786. 3. Schreeder DM, et al. 2008. 38:3159.
Gene ID: 343413
UniProt: View information about FcRL6 on UniProt.org
Clone: 7B7/FcRL6
Regulatory Status: RUO
Other Names: FcRL6, Fc receptor like 6
Isotype: Mouse IgG1, κ