Biolegend, 375026, PE/Cyanine7 anti-human CD159c (NKG2C) Antibody, 100tests

CD159c, also known as NKG2C or KLRC2, is a type II transmembrane protein. It belongs to the killer cell lectin-like receptor family also known as the NKG2 family. It is expressed on NK and NKT cells and T cell subsets. NKG2C is an activating NK cell receptor and it is expressed as a heterodimer with CD94. In humans, the NKG2C/CD94 complex interacts with HLA-E on target cells and delivers activating signals through immunoreceptor tyrosine-based activation motifs.
100tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human NKG2C/CD94-transfectants
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool).
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Blue Laser (488 nm)Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes: S19005E does not crossreact with mouse CD159c.
RRID: AB_3720520 (BioLegend Cat. No. 375025) AB_3720520 (BioLegend Cat. No. 375026)
Structure: Type II transmembrane proteins of the C-type lectin superfamily
Distribution: NK cells, NKT cells, T cell subsets
Function: Activating NK cell receptor
Ligand/Receptor: HLA-E
Cell Type: Lymphocytes, NK cells, NKT cells, T cells
Biology Area: Immuno-Oncology, Immunology
Molecular Family: Immune Checkpoint Receptors
Antigen References: Malisheni M, et al. 2017. Front Immunol. 8:863. Sáez-Borderías A, et al. 2009. J Immunol, 182:829. Kamiya T, et al. 2019. J. Clin. Invest. 129:2094.
Gene ID: 3822
UniProt: View information about CD159c on UniProt.org
Clone: S19005E
Regulatory Status: RUO
Other Names: Killer Cell Lectin Like Receptor C2, KLRC2, NK Cell Receptor C
Isotype: Mouse IgG1, κ